Biological activities of newly prepared saframycins.
نویسندگان
چکیده
منابع مشابه
Structure-activity relationships of saframycins.
In vitro antitumor activities of 13 saframycins, including the potent antitumor component, saframycin A, were determined with the highly sensitive established cell line of L1210 mouse leukemia to investigate structure-activity relationships. Saframycins which lack the alpha-cyanoamine group or the alpha-carbinolamine group exhibited much lower cytotoxic activity than saframycin A. The modificat...
متن کاملNewly Discovered Activities for Calcitriol
16 ROGERS, B. L., SOBNOSKY, M. G. & SAUNDERS, G. F. (1985). Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster. J . Biol. Chem. (in press). 17 PICARD, D. & SCHAFFNER, W. (1984). A lymphocyte-specific enhancer in the mouse immunoglobulin gene. Nature 307, 80-82. 18 EPHRUSSI, A., CHURCH, G. M., TONEGAWA, S. & GILBERT, W. (1985). Science 227, 134-140....
متن کاملBiological activities of leupeptins.
Leupeptins, leupeptin Pr and leupeptin Ac, strongly inhibit proteolysis by plasmin, trypsin and papain, but do not inhibit proteolysis by <#-chymotrypsin. The inhibition is competitive with substrates. The inhibitory effect on esterolysis by plasmin and trypsin is weaker than on proteolysis. The results with derivatives of leupeptins which contain carboxyl or alcohol instead of aldehyde and of ...
متن کاملBiological Activities of Emetine
Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug. It inhibits both ribosomal and mitochondrial protein synthesis and interferes with the synthesis and activities of DNA and RNA. For this reason, it has been a vital tool to pharmacologists and...
متن کاملBiological activities of complement.
Complement is a system of serum proteins whose main function is to defend the body against infection. Although it has a reputation as a dauntingly complex system, this results chiefly from confusion in the nomenclature, which has varied considerably with time as more components were discovered, for example as ‘component C3’ became subdivided into several components one of which is still called ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1987
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.40.1640